Production-Possibility Frontier Essay Example

Production-Possibility Frontier Paper Production-possibility frontier In economics, a production-possibility frontier (PPF) or â€Å"transformation curve† is a graph that shows the different quantities of two goods that an economy (or agent) could efficiently produce with limited productive resources. Points along the curve describe the trade-off between the two goods, that is, the opportunity cost. Opportunity cost here measures how much an additional unit of one good costs in units forgone of the other good. The curve illustrates that increasing production of one good reduces maximum production of the other good as resources are transferred away from the other good. edit] Productive efficiency, opportunity cost, and allocative efficiency The production possibilities curve shows the maximum feasible (obtainable) amount of one commodity for any given amount of another commodity, as of the societys technology and the amount of factors of production available. The concept is used to show the options open to a firm, individual, household, or economy for a 2-good world. In microeconomics, the 2-good case readily generalizes to the n-good case. In macroeconomics, it illustrates the production possibilities available to a nation or economy (corresponding roughly to macroeconomic notions of potential output at a given point on the curve) for broad categories of output. All points on a production possibilities curve are points of maximum productive efficiency or minimum productive inefficiency: allocated such that it is impossible to increase the output of one commodity without reducing the output of the other. That is, there must be a sacrifice, an opportunity cost (given by the slope of the curve in absolute value), for increasing the production of a good by one unit. Conversely, points inside the frontier are feasible but productively inefficient. Point A in the diagram for example, shows that FA of food and CA of computers can be produced when production is run efficiently. So can FB of food and CB of computers (point B). For a firm, a point on the curve is productively efficient but, given market demand, could be less profitable than another point on the curve. Equilibrium for the firm with given resources is at the most profitable and productively efficient point on the PPF. There is a parallel for an economy as well. It may have productive efficiency but not allocative efficiency. Markets and other institutions of social decision-making (such as government, tradition, and community democracy) may lead to the wrong combination of goods being produced (and the wrong mix of resources allocated) compared to what individuals would prefer, given what is feasible on the PPF. All points to the right of (or above) the curve are infeasible for given resources. A move from point A to point B indicates an increase in the number of computers produced. But it also implies a decrease in the amount of Food produced. This decrease is the opportunity cost of producing more computers. We will write a custom essay sample on Production-Possibility Frontier specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Production-Possibility Frontier specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Production-Possibility Frontier specifically for you FOR ONLY $16.38 $13.9/page Hire Writer As mentioned, the two main determinants of the curve are production functions (reflecting the available technology) and available factor endowments. If the technology improves or the supplies of factors of production increase, the production possibility frontier shifts to the right (upward), raising the amount of each good that can be produced. A military or ecological disaster might move the PPF inward and to the left. In neoclassical economics, production possibility frontiers can easily be constructed from the contract curves in Edgeworth box diagrams of factor intensity. In other interpretations (often seen in textbooks), the concave production-possibiliity frontier reflects the specialized nature of the heterogeneous resources that any society uses: the opportunity cost of shifting production from one mix to another (e. g. , from point A to point B) reflects the costs of using resources that are not well-specialized for the production of the good which is being produced in greater quantity. The line curve in Figure is not straight but is concave to the origin (that is, curved inward toward the axes). This can represent an assumed disparity in the factor intensities and technologies of the two sectors. That is, as we specialize more and more into one product, the opportunity costs of producing that product increase, because we are using more and more resources that are poorly suited to produce it. With increasing production of computers, workers from the food industry will move to it. At first, the least qualified (or most general) food workers will help start making computers. The move of these workers has little impact on the opportunity cost of increasing computer production: the loss in food production will be small. This cost of successive units will increase as more of specialised food manufacturers are attracted. For example, in the second diagram, the decision to increase the production of computers from 5 to 6 (from point Q to point R) requires a minimum loss of food output. However, the decision to add a tenth computer (from point T to point V) has a much more substantial opportunity cost. The the neoclassical interpretation, if the factor intensity ratios in the two sectors were constant at all points on the production possibilities curve, the curve would be linear and the opportunity cost would remain the same, no matter what mix of outputs were produced. In other interpretations, a straight-line production-possibiliity frontier reflects a situation where resources are not specialized and can be substituted for each other with no cost. Products requiring similar resources (bread and pastry, for instance) will have a nearly straight PPF, hence constant opportunity costs (when increasing production rates). [edit] The marginal rate of transformation The slope of the production-possibility frontier (PPF) at any given point is called the marginal rate of transformation (MRT). It describes numerically the rate at which one good can be transformed into the other. It is also called the (marginal) opportunity cost† of a commodity, that is, it is the opportunity cost of X in terms of Y at the margin. It measures how much of good Y is given up for one more unit of good X or vice versa. The shape of PPF is commonly drawn as concave downward to represent increasing opportunity cost with increased output of a good. Thus, MRT increases in absolute size as one moves from the top left of the PPF to the bottom right of the PPF. Marginal Rate of Transformation If, for example, the (absolute) slope at point BB in the diagram is equal to 2, then, in order to produce one more computer, 2 units of food production must be sacrificed. If at AA for example, the marginal opportunity cost of computers in terms of food is equal to 0. 25, then, the sacrifice of one unit of food could produce 4 computers. The marginal rate of transformation can be expressed in terms of either commodity. The marginal opportunity costs of computers in terms of food is simply the reciprocal of the marginal opportunity cost of food in terms of computers.

Behaviors and Processes team leadership project and time management essays

Behaviors and Processes team leadership project and time management essays It is often asserted that life is a journey, not a destination. In other words, the process of learning as a group is often more instructive than a review of an individual or even a collective final product. One of the most instructive aspects of working as a team is the ability to observe and critically evaluate different time management strategies over the course of the learning process. To do so is particularly critical in the world of business, particularly businesses the embrace individuals from a For instance, different cultural contexts have different approaches towards time and time management. It has been anecdotally as well as anthropologically observed that some cultures (such as France and Italy) have a very diffuse attitude towards punctuality, where one's individual relational and immediate social contextual needs often surmount the desire to meet specific time goals. Thus,"10am' can mean anytime from 9:45 to 10:30. Other, more punctual cultures, such as our own are much more focused on the goal of meeting at specific hours. One recent immigrant to America commented "the Yellow Pages were something brand new for me when I first arrived in the U.S. I still had the habit of going to a store only to find out that it didn't have what I needed. My wife used to ask, Didn't you call before going there'' The notion of calling ahead of time requires planning and a future orientation, where my upbringing was in a present- Even within the U.S., of course, Northeasterners are supposed to be much more obsessed with meeting specific time limits and conforming to specific strictures than those from the West Coast and South. Even within our own team variations in temporal attitudes were observed. Peak and valley performance and times This does not mean that one attitude towards time management is ...

Macro and Microeconomics Essay Example | Topics and Well Written Essays - 2000 words

Macro and Microeconomics - Essay Example Price mechanism; therefore, solve the problem of allocating scarce resources by ensuring they are allocated through competition in a free market. Moreover, price mechanism helps industries to produce efficient product that of high quality. The competition between firms ensures that the most efficient remain on the market while its edges others that are inefficient out of the market (Moon 2013). Efficient firms produce quality goods at a cheaper price compared to the inefficient ones. The high cost of production makes inefficient industries set a price that will cover the cost of production and thus they price at a higher price than efficient firms. The high priced goods become uncompetitive in a free market and draw the firm out of business (Mukhopadhyay 2). Price also serves the function of discounting to determine the cost as well as the amount or size of a commodity. However, price comprises the joint charge of goods and the profit attached to it. Therefore, price serves to determine the amount to be produced and the effectiveness of it. Price, therefore, serves as a planning tool to making the economic decision as to where the economy is to be taken (The fundamentals of market economy self-regulation). Price also stimulates firms and industries into production process due to high profit guaranteed when a firm is involved in large scale production. Lastly, price help in the distribution of income and resources to the most efficient industries in the market.

(choice of topics listed below) and its implications for WORLD Research Paper

(choice of topics listed below) and its implications for WORLD REGIONAL GEOGRAPHY - Research Paper Example A region is usually defined as a part of the surface of the earth having various characteristics that makes the area unique from other areas. The regional geography looks to focus on the unique and specific characteristics of various places related to the economy, culture; climate, environmental and political factor. Study of regional geography started develop in United States and Europe during the period between World War I and World War II as geographers were looking for a way to make geography a strong credible university level subject. (Marston, Knox, and Liverman 205) Globalization on the other hand refers to the increasing interconnectedness and interdependence of places globally. The major implications of globalization are the expansion of global connections with relation to the network and relation leading to increasing awareness about the world. The present study looks to analyze the implications of globalization on the world regional geography. The core concept of the study is of great importance as there have been very few studies similar to the mentioned one. Analysis and Findings Various geographers like Peter Dicken have often criticized fellow geographers for missing out on the topic of globalization and its impact of world regional geography. Mr. ... Also it is quite strange that very few geographers are looking to discuss the relationship between globalization and geography. All in all there is a belief that geographers can play a major role in the overall geographic debate. There is a misconception among some of the geographers over the fact that the world is flat. However, it is not quite true. The concept of the world is flat has often been mentioned in the Thunen’s agricultural location theory, central place theory and industrial location theory by Weber (Hobbs 301). Geographers became nervous in the early 90’s when the promoters of globalization started to predict convergence, locations, and places, end of distance, global villages and geography. One can also find defenses coming out from the business world, media, social sciences and geography. The most fundamental arguments that have been summarized by Yeung include: The global economy is not a singular production factory. It is a regional production world a nd hence it is contested by regionalization which is also happens to be the major drive of global economy; junction and global cultures have emphasized on the awareness of cultural responses and local differences; globalization does not refer to the end of states and nations as the primary point of political governance. The message of the geographers which includes various publications has been hardly able to reach the minds of the non geographic junction of promoters and hence the evolution of globalization ahs continued the end of regional geography debate. The lack of appropriate dialog between regional and systematic geographers has some reduced the impact of

Marketing plan for Milk Essay Example | Topics and Well Written Essays - 1250 words

Marketing plan for Milk - Essay Example A marketing plan is prepared for assisting the business in integrating the total marketing efforts. The planning process begins with an attempt by the company to size up its present market situation and the factors responsible for it. Such a plan ensures a systematic approach to developing products and services to meet and satisfy the consumer's needs. An established milk beverage manufacturer is introducing a completely new product - flavored milk beverages for the segment 6-12 years old. The marketing plan for this product will be as follows;Current marketing situation: Flavoured milk also known as value added milk is being placed by British companies for different segments of the market. are increasingly targeting the value-added milk for growth opportunities as they re-align their businesses and move away from commodity products. Current competing cost/profit ratio: In view of the stiff competition and presence of big players in the market place, the cost/profit ratio is likely to remain high with higher cost inputs and lower returns. We cannot put a higher price tag to recover all the costs involved.Opportunity and issue analysis: So far in particular the flavoured milk market has managed to compete as some sectors of the milk and cream market still suffer from a lack of innovation and marketing support. Healthy eating trends are having an impact on the market which has started favouring semi-skimmed and skimmed milk.Entry/exit barriers: White milk accounts for 96% of the market share. Well established branded products are also in the market. ... Flavoured milk is facing increased competion in the chilled segment from functional yogurt drink. Benefiting from current Milk campaign: An increased awareness amongst the consumers about the benefits of flavoured milk. Objectives: To create a niche for itself in the existing market and mainly amongst the targeted segment. Money Goals: To start with the company is ready to bear some losses for the initial period but the efforts will continue with renewed vigour for attaining the breakeven point as soon as possible. Sales goals: In the first year of operation, company can target to lure away at least 2-3% of the existing market. The company will try to gain as many new customers as possible. Profit goals: Company is not looking for profits from the word go. It plans to go ahead with a longer perspective. But at the same time it is worth pondering that business needs to payback to financers, investors, employees and other stakeholders. Market Goals: The market will be 6-12 yrs old kids. That means we'll have to target the schools, schools administrators and other faculty so that they inform the students about the arrival of a new quality flavoured milk in the market. Market Share: Since we are a new entrant, that means we'll have to be realistic in our approach. We must understand that we'll be able to create the marketing space for our product only when we take good care of the consumer needs and quality. Consumer loyalty: Let us not expect the tiny tots to be our loyal consumers overnight, as they are the one's who are very difficult to divert enblock towards a new product. Their consumption pattern will be affected with the influence of their parents and teachers. Marketing communication and promotional strategies are

CAR-T Cells in the Treatment of Chronic Lymphocytic Leukemia

CAR-T Cells in the Treatment of Chronic Lymphocytic Leukemia Abstract Cancer has always been a difficult problem to be solved by humans, of which leukemia is one of them. With the development of gene recombination technology and our in-depth understanding of cancer, chimeric antigen receptor T cells (CAR-T) can be carried out in clinical trials. Recently, CAR-T has made new progress in the treatment of acute and chronic lymphocytic leukemia. CAR-T cells are T-cell receptor gene and anti-CD19 antibody gene binding, transfection to T cells, in vitro amplification after transfer to patients for the treatment of leukemia new immunotherapy. The surface of the modified CAR-T cells has a specific binding site, which can recognize the CD19 antigen on the surface of B cells in lymphoblastic leukemia. CD19 antigen can stimulate the continuous activation and proliferation of CAR-T, CAR-T in the patients body can be multiplied hundreds of times, effectively killing acute and chronic lymphocytic leukemia cells. Keywords: car-t cell therapy, chronic lymphocytic leukemia 1. CAR-T principle With the development of gene recombination technology, the specific antibody can be stably expressed on the surface of T cells, so that it has a specific antigen epitope. Chimeric antigen receptor T cell immunotherapy is carried out on the basis of a cellular immunotherapy. The chimeric anti-gen receptor (CARs) is an antigen-recognition domain composed of a specific antibody in the extracellular domain and an antigen-chimeric protein composed of the intracellular CDC3-ÃŽ ¶ chain or FcÃŽ ³I protein linked to the transmembrane domain[1]. After the CARs are recognized and stimulated by specific antigens, they can provide activation signals for T cells and conduct the signals through the intracellular domain, which results in the activation of cells, which are CARs dependent cell activation and cytotoxicity, and cytokines Release [2]. In order to increase the cytotoxicity of CARs, the proliferation of signal transduction was achieved by constructing co-stimulatory molecules connected to the extracellular CD3CÃŽ ¶ in the intracellular domain, resulting in a multiplication of the cell killing effect, which greatly enhanced the CARs Cell killing effect [3]. Generation of CARs intracellular contains only one activation domain, so its specificity in the identification of tumor cell-associated antigens after killing effect is very limited [4]. Second-generation CARs contain an activation domain and a co-stimulatory domain, such as CD28 or 4-1BB [5-6]. The three-generation CARs are composed of the activation domain and multiple co-stimulatory domains, such as CD27, CD28, 4-1BB and OX40. The increase of these domains not only increases the ability of CAR-T cells to specifically recognize TAA and binding , More able to significantly extend the extracellular area of à ¢Ã¢â€š ¬Ã¢â‚¬ ¹Ãƒ ¢Ã¢â€š ¬Ã¢â‚¬ ¹the cell signal transmission, causing lower levels of cell killing cascade [7]. With the improvement of structural design of CARs and the improvement of tumor targeting and kil ling, the researchers have constructed many other intracellular co-stimulatory molecular structures, including CD134, Lck, ICOS and DAP10 [8]. In addition, CD19-derived CAR-T cells were further engineered by researchers at the Duke University Center for Immunology to autocrine IL-12, which may or may not be required in specific syngeneic tumor models Pretreatment chemotherapy, if further extended to clinical patients can be in the lower side effects to obtain better efficacy [9]. Therefore, the continuous innovation of CARs related technologies is not only the structural optimization, but also the construction of more costimulatory molecules in function. The efficiency and function of CAR-T cells will be further improved. 2. Obtain specific CAR-T cells CD19 is a potential target for B-cell neoplasms and can be expressed in normal B cells, follicular dendritic cells, malignant B cells, and precursor B cells in addition to hematopoietic stem cells [10]. Acute and chronic lymphocytic leukemia is usually accompanied by CD19 expression, but in other lymphoid system tumor expression is not the same. Jena and others through genetic modification technology for the first time applied to chronic viral vector, the CD19 + specific chimeric antigen receptorand expression of B cells, transfected into the patients T cells, the transformation of T cells called CD19-specific CAR -T cells [11]. These T cells in vitro after a large number of amplification, re-enter the acute and chronic lymphocytic leukemia patients play a role in the body. CD19-specific CAR-T cells are able to recognize leukemia specific CD19 targets and release B-cells from CD19 cells by releasing a variety of cytokines, thereby promoting the clearance of malignant tumor cells. The results show that, after retroviral gene transfection of T cells, in clinical applications is safe and effective [12]. CD19-specific CAR-T cells have been shown to be effective in attacking CD19 + tumor cell lines and in vivo B-cell tumors in animals [13]. In immunodeficient mice, CD19 + T cells can be effectively removed by the addition of CD19 + T cells [14]. 3. CAR-T cells in the treatment of chronic lymphocytic leukemia Chronic lymphocytic leukemia (CLL) is a slow-growing, inert B-cell leukemia, usually occurring in adults, and many patients can have no symptoms for several years, compared with other types of leukemia. Currently CLL has no specific treatment options, no obvious symptoms of CLL advocates observation and wait, mainly symptomatic treatment, drug therapy is difficult to achieve long-term remission and clinical cure. Genetically modified CAR-T cells have a significant therapeutic effect on B-cell malignancies. The New England Journal reported in June that the June Task Force [15] successfully treated 3 patients with CLL with CAR-T cells for the first time, 2 of whom were still in complete remission after 2 years of follow-up. They subsequently found that [16], the infusion of CAR-T cells in patients with peripheral blood and bone marrow in a large number of survival, proliferation in the body more than 1000 times, effective removal of CLL cells function can be maintained for more than 6 months. Not only that, some CAR-T cells are even in the form of memory cells that produce a rapid response when re-exposed to CLL cells. The mechanisms by which CAR-T cells proliferate and survive in vivo are unclear, probably due to the activation or release of cytokines by normal B cells and CD19-expressing leukemic cells in the internal environment. The cytokines such as IFN-r, CXCL9, IL-6 and soluble IL-2 receptor increased significantly after CAR-T cells entered the body, reaching a peak on the 23rd day after transfusion. Elevated cytokines in bone marrow were consistent with reduced levels of leukemic cells, but TNF levels in peripheral blood and bone marrow did not vary significantly. The number of CAR-T cells in vivo was detected by RT-PCR, and the ratio of cells increased 1000-fold on the 21st day after transfection, accounting for more than 20% of the peripheral blood lymphocytes. The number of CAR-T cells was consistent with the time of oncolytic syndrome and elevated lev els of cytokines. The doubling time of CAR-T cells in peripheral blood was about 1.2 days and the half-life was 31 days. It is noteworthy that cytotoxic side effects such as cytokine release syndrome and macrophage activation syndrome may occur after treatment with CAR-T cell immunotherapy. These symptoms and children hemophagocytic syndrome, lymphoproliferative disease occurs in similar cytokine storm [17]. Cytokine storm is due to CAR-T cells kill B cells caused by tumor cell lysis, characterized by inflammation, long-term fever, hepatosplenomegaly, cell reduction. At this point the laboratory examination of patients with ferritin, triglyceride, transaminase, bilirubin, soluble IL-2 receptor a chain were increased and fibrinogen reduction [18]. CAR-T cells after the input, the patients peripheral blood and bone marrow loss of B cells and hypogammaglobulinaemia up to 6 months or more, but patients do not necessarily have recurrent infection. If the clinical symptoms require symptom atic treatment, the number of CAR-T cells in the patients body or the anti-tumor effect will not be significantly affected. In the past, patients treated with rituximab, after a few months of treatment, B cells can gradually pick up. Whether this phenomenon will occur in patients with CAR-T cell immunotherapy is still unclear. Because CAR-T cells can proliferate extensively and produce cytotoxicity in vivo, CAR-T cell-specific detection is needed in the course of clinical treatment [19], and timely prevention of adverse reactions occurs. 4. Adverse reactions and treatment Although CAR-T cell therapy has achieved surprising clinical results, but have to admit that there are still many cell treatment process risk, adverse reactions after treatment for the treatment of a great test. Because CAR-T can proliferate in vivo and produce severe cytotoxic effects on target cells, the most common and serious is cytokine release syndrome (CRS) [20]. In the current report of CAR-T cells in the treatment of blood cancer cases, almost all appeared in different severity of the CRS response. CRS is mainly due to the large number of cells after activation, including circulating IL-6, ferritin, INFÃŽ ³, IL-2, granulocyte colony stimulating factor IL-10, IL-8, IL-5, including rapid increase in cytokines Caused by fever without cause of infection, persistent hypotension, and even reports of neurological toxicity such as seizures [21-22]. CRS was observed in 48 of the 51 patients treated with CD19-modified CAR-T cells (94%) and serum ferritin levels were greater than 1000 mg / dl in all patients with severe CRS 4-5 C The relationship between the increase of CRP and the course of disease was similar to that of ferritin, but serum C reactive protein and ferritin level did not have significant effect on the prediction of CRS progression. Further, they used 10 healthy volunteers as baseline and found that severe CRS responses within 1 month after CAR-T cell therapy were associated with 24 cytokines including IFNÃŽ ³, IL-6, SGP-130, and SIL6R Serum levels of the peak correlation [23]. Patients with severe CRS response to the survival of patients posed a huge risk, patients with severe hypotension or shock, respiratory distress syndrome, neurotoxicity, liver and kidney dysfunction, it must actively deal with the situation. In addition to the use of vasoactive drugs, tracheotomy and enhanced supportive therapy, the application of IL-6 receptor inhibitor tincture of monoclonal antibody is necessary by inhibiting IL-6 binding to cells and soluble IL-6 And bl ock its classic and bypass IL-6 signal pathway, so after receiving the monoclonal antibody treatment, many patients quickly achieved a good clinical response [24]. CRS can be divided into 5 levels, different levels of recommended CRS treatment is different, it is generally recommended priority early adequate use of trastuzumab to prevent severe CRS response, but because IL-6 mAb is not easy through the blood-brain barrier, 3 to 4 neurotoxic patients, may be preferred to use glucocorticoids to prevent severe CRS. Therefore, IL-6 monoclonal antibody can be relatively early application, can be controlled for CRS and does not affect the efficacy of CAR-T 5. Summary and outlook Nowadays, the clinical application of CAR-T cell therapy, especially the treatment of CD19 CAR-T in hematologic tumors, has made great achievements and the application potential of adoptive immunotherapy as the main representative of CAR-T cell immunotherapy Is very broad. Not only in the blood disease, but also in solid tumors and many benign or chronic diseases, it also has a lot of potential applications. With the development of gene recombination technology and antigen protein construction technology, more CAR-T has been applied to precise targeted therapy. In addition, epitopes expressed on the surface of different blood tumor cells, such as: CD20, CD22, CD34, etc. may also be used as future treatment of other refractory blood diseases targeted to disease treatment to bring a new direction. One of the patients treated with CD19-modified CAR-T cells for MLL rearrangement of B-cell acute lymphoblastic leukemia showed that two patients developed AML after one month of treatment, wh ich may be related to the CD19-negative cellular immune escape Of a mechanism-related [25]. Therefore, the application of CAR-T in combination with multiple epitopes and the sustained killing effect of CAR-T cells in vivo may bring new hope to these cases. There have also been advances in the use of checkpoint inhibitors in combination with CAR-T in the treatment of animals such as AML [26]. However, CAR-T therapy is still a significant clinical risk of adverse treatment, therefore, CAR-T therapy to avoid the safety and toxicity is also a clinical problem to be solved. At present, CAR-T cell therapy for specific antigenic epitopes is combined with nonspecific traditional therapy for tumor cells. It is also a safe and reasonable regimen for the treatment of these diseases, not only killing the tumor cells completely, reducing immune escape and ineffective CAR-T cell immunotherapy, in turn, reduces the dose of non-targeted therapies such as prior chemotherapy and the consequent toxic reactions. Therefore, in the process of discovering new target antigens and constructing precise immunotherapy, The combination of non-targeted drugs and hematopoietic stem cell transplantation is also the research direction of CAR-T cell therapy for a long time. Thus, CAR-T cell therapy has provided new hope for refractory hematologic malignancies, and although there is a pleasing therapeutic effect, more research and further clinical trials are needed, Multi-angle, combined with previous and recent targeted therapy experience, will give CAR-T cell therapy to bring a broader application prospect and exciting clinical efficacy. References: [1] Deniger DC, Switzer K, Mi T, et al.Bispecific T-cells expressing polyclonal repertoire of endogenous gammadelta T-cell receptors and introduced CD19-specific anti receptor[J].Molecular therapy:the journal of the AMerican society of gene therapy, 2013, 21(3):638-647. [2] Jena B, Dotti G, Cooper LJ.Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor[J].Blood, 2010, 116(7):1035-1044. [3] Wang J, Jensen M, Lin Y, et al.Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains[J].Human gene therapy, 2007, 18(8):712-725. [4] Jensen MC, Popplewell L, Cooper LJ, et al.Antitransgene rejection reponses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans[J].Biology of blood and marrow transplantation:journal of the American society for blood and Marrow transplantation, 2010, 16(9)à ¯Ã‚ ¼Ã… ¡1245-1256. [5] Kowolik CK, Topp MS, Gonzalez S, et al.CD28 Costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of aoptively tyansferred T cell[J].Cancer research, 2006, 66à ¯Ã‚ ¼Ã‹â€ 22à ¯Ã‚ ¼Ã¢â‚¬ °Ãƒ ¯Ã‚ ¼Ã… ¡10995-11004. [6] Sanchez-paulete AR, Labiano S, Rodriguez-ruiz ME, et al.Deciphering CD137(4-1BB) signaling in T cell costimulation for translation into successful cancer immunotherapy[J].European journal of immunology, 2016, 46(3):513-522. [7] Pule MA, Straathof KC, Dotti G, et al.A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of Primary human T cell[J].Molecular therapy:the journal of the American society of gene therapy, 2005, 12(5):933-941. [8] Zhao Y, Wang QJ, Yang S, et al.A herceptin-based chimeric antigen rcetor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity[J].Journal of immunology, 2009, 183(9):5563-5574. [9] Pegram HJ, Lee JC, Hayman EG, et al.Tumor-targeted T cells modified to secrete IL-12 cradicate systemic tumors without need for prior conditioning[J].Blood, 2012, 119(18):4133-4141. [10] Morgan RA, Yang JC, Kitano M, et al. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing Eà ¯Ã‚ ¼Ã‚ ²BB2. Mol Ther, 2010; 18 ( 4) : 843-851à ¯Ã‚ ¼Ã… ½ [11] Jena B, Dotti G, Cooper L. à ¯Ã‚ ¼Ã‚ ²edirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor. Blood, 2010; 116 ( 7) : 1035-1044à ¯Ã‚ ¼Ã… ½ [12] Scholler J, Brady TL, Binder-scholl G, et al. Decade-long safety and function of retroviral-modified chimeric antigen receptor T cellsà ¯Ã‚ ¼Ã… ½ Sci Transl Medà ¯Ã‚ ¼Ã…’2012; 4( 132) : 132ra53à ¯Ã‚ ¼Ã… ½ [13] Brentjens RJ, Latouche JB, Santos E, et al.Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15.Nat Med, 2003; 9( 3) : 279-286. [14] Brentjens à ¯Ã‚ ¼Ã‚ ²J, Santos E, Nikhamin Y, et al. Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts.Clin Cancer à ¯Ã‚ ¼Ã‚ ²es, 2007; 13( 18) : 5426-5435. [15] Porter DL, Levine BL, Kalos M, et al.Chimeric antigen receptormodified T cells in chronic lymphoid leukemia.N Engl J Med, 2011; 365( 8) : 725-33à ¯Ã‚ ¼Ã… ½ [16] Kalos M, Levine BL, Porter, DL, et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia.Sci Transl Med, 2011; 3( 95):95 ra73. [18] Janka G.Familial and acquired hemophagocytic lymphohistiocytosis.Annu rev Med, 2012; 63( 1) : 233-246à ¯Ã‚ ¼Ã… ½ [19] Kohn DB, Dotti G, Brentjens R, et al. CARs on track in the clinic.Mol Ther, 2011; 19( 3) : 432-438à ¯Ã‚ ¼Ã… ½ [20] Maude SL , Barrett D, Teachey DT, et al. Managing Cytokine Release Syndrome Associated With Novel T Cell-Engaging Therapies[J].Cancer journal(Sudbury, Mass), 2014, 20(2):119-122. [21] Grupp SA, kalos M, Barrett D, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia[J].The New England journal of medicine, 2013, 368(16):1509-1518. [22] Kochenderfer JN, Dudley ME, Feldman SA, et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells[J]Blood, 2012, 119(12):2709-2720. [23] Lee DW, Gardner R, Porter DL, et al. Current concepts in the diagnosis and management of cytokine release syndrome[J]Blood, 2014, 124(2):188-195 [24] Teachey DT, Rheingold SR, Maude SL, et al.Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy[J].Blood, 2013, 12(26):5154-5157 [25] Gardner R, Wu D, Cherian S, et al.Acquisition of a CD19-neg-ative myeloid phenotype allows immune escape of MLL-rear-ranged B-ALL from CD19 CAR-T-cell the rapy[J].Blood, 2016, 127(20):2406-2410. [26] Saad S Kenderian MR, OL ga Shestova, Michael Klichishky, et al.Idntification of PD1 and TIM3As Checkpoints that Limit Chimeric Anti gen Receptor T Cell Efficacy in Leukemia[j]Bood, 2015, 126(23):852-852

I Wanted to Share My Father’s World Essay -- Literary Analysis, Jimmy

Although single parenthood is on the rise in homes today, children still often have a father role in their life. It does not matter who the part is filled by: a father, uncle, older brother, grandfather, etc...; in almost all cases, those relationships between the father (figure) and child have lasting impacts on the youth the rest of their lives. In â€Å"I Wanted to Share My Father’s World,† Jimmy Carter tells the audience no matter the situation with a father, hold onto every moment. As Carter opens the poem, he tells how at this point in his life, he still has this essential want for things his own father presented him growing up. In the beginning, he expresses he has this â€Å"†¦pain [he] mostly hide[s], / but [that] ties of blood, or seed, endure† (lines 1-2). These lines voice how he longs for his father and just how painful it is without him at his side. In addition, he still feels â€Å"the hunger for his outstretched hand† (4) and a man’s embrace to take [him] in† (5). Furthermore, Carter explains how this â€Å"pain† he â€Å"feel[s] inside† (3) are also due to his â€Å"need for just a word of pr...

Business Ownership Choices †10 Mark Question Essay

Orion Designs was established five year ago by Amita Patel and her friend, Yi Ling, after they both finished Art and Design courses. Orion Designs is run as a partnership between the two women. There are currently no other partners. Amita and Yi create hand drawn designs in their studio which is located on an industrial estate. These designs are then sent to another business where a computer is used to put the designs onto transfers. When Amita and Yi get these transfers back, they are put onto mugs and plates purchased from a separate pottery company. Orion Designs then sells the finished mugs and plates as souvenirs. Orion Designs has been making increased profits each year. Amita and Yi now want to expand the business. They could increase the range of items onto which they put the transfers (eg. Mousemats), or perform all of the production processes at Orion Designs. Amita and Yi are aware of the risks involved in expanding the business. Even though they have already invested their own money in the business, there may be a need for additional finance as well as more employees. Actual Question: Amita and Yi have recently had a meeting with a local business advisor about their plan for the expansion of Orion Designs. They were given three possible options: * Option 1- stay as they are; * Option 2- take on additional partners * Option 3 – turn the business into a private limited company. Recommend the best option for Amita and Yi, explaining why the other options were not chosen. Introduction: Amita and Yi are two friends who have a business that puts designs onto pottery. They are currently a partnership but are trying to work out whether they should change the ownership type of their business in order to expand. Paragraph 1 (Analysis of Option 1 and Option 2) The business is currently a partnership so Amita and Yi both have unlimited liability. This means they would have to sell their personal assets if the business went into debt. If they took option 1 this disadvantage would still remain. Option 1 is low risk as they are not doing anything different but it might be difficult for them to expand as they won’t have any additional finance. If they know people who want to join their business then they could take on additional partners, these would have unlimited liability as well. This would bring money into the business but these new partners might want a say in running the business and it might not be what Amita and Yi want, this could lead to arguments. Paragraph 2 (Analysis of Option 3) As a private limited company, the owners of Orion Designs have the benefits of limited liability so they can only lose the amount of money that they invested in the company. So the owners of the business would have more security. If Orion Designs want to expand and have new ranges then they will need more money, if they become ltd they could raise the money they need by having shareholders. This would be an advantage to Orion Designs. At the moment all profits go to Amita and Yi, if they were to become a private limited company they would receive less profits themselves as they would have to pay dividends to all shareholders. Conclusion At the moment there are only two partners, Amita and Yi so they will be limited in the amount of money they can invest but they can make all the decisions themselves. If it were to become a ltd then other shareholders would be able to make decisions and Amita and Yi would lose some control of their business. There are also legal formalities involves in becoming a ltd which would take time and cost money. In order to secure the future of the business and expand I recommend that Orion Designs takes option 2 and stays as a partnership but invites other partners to invest in the business. This way they get the advantage of more capital in the business but do not have to spend a lot of time and money becoming an ltd.

Dr. Martin Luther King, Jr. - Status of His Dream Today

Dr. Martin Luther King, Jr. - Status of His Dream Today On August 28, 1963, a quarter of a million people, mostly African Americans, gathered at the National Mall for The March on Washington for Jobs and Freedom. They came to express their discontent with the persistent racism of the nation, particularly that of the southern states where Jim Crow laws maintained racially separate and unequal societies. This gathering is considered a major event within the Civil Rights movement, and a catalyst for the passage of the Civil Rights Act of 1964, for subsequent protests that followed, and for the Voting Rights Act of 1965. This day is most well remembered, though, for a spontaneous description of a better future given by The Reverend Dr. Martin Luther King, Jr., during his famous I Have a Dream speech. Prompted by Mahalia Jackson, who urged him to break from his prepared words to tell the crowd about his dream, King said: I say to you today, my friends, so even though we face the difficulties of today and tomorrow, I still have a dream. It is a dream deeply rooted in the American dream.I have a dream that one day this nation will rise up and live out the true meaning of its creed: We hold these truths to be self-evident: that all men are created equal.  I have a dream that one day on the red hills of Georgia the sons of former slaves and the sons of former slave owners will be able to sit down together at the table of brotherhood.  I have a dream that one day even the state of Mississippi, a state sweltering with the heat of injustice, sweltering with the heat of oppression, will be transformed into an oasis of freedom and justice.I have a dream that my four little children will one day live in a nation where they will not be judged by the color of their skin but by the content of their character.  I have a dream today.  I have a dream that one day, down in Alabama, with its vicious racists, w ith its governor having his lips dripping with the words of interposition and nullification; one day right there in Alabama, little black boys and black girls will be able to join hands with little white boys and white girls as sisters and brothers. I have a dream today. The Philosophy and Practicalities of Dr. Kings Dream Dr. Kings dream of a society no longer plagued by racism reflected the one he and other members of the Civil Rights movement hoped would be the result of collective efforts to end systemic racism. Taking account of the many initiatives that Dr. King was a part of, and leader to, during his life, one can see the components and bigger picture of this dream. The dream included an end to racial segregation; an unimpeded right to vote and protection from racial discrimination in electoral processes; equal labor rights and protection from racial discrimination in the workplace; an end to police brutality; an end to racial discrimination in the housing market; minimum wage for all;  and economic reparations for all people hurt by the nations history of racism. The foundation of Dr. Kings work was an understanding of the connection between racism and economic inequality. He knew that Civil Rights legislation, useful though it would be, would not erase 500 years of economic injustice. So, his vision of a just society was premised on economic justice writ-large. This manifested in the Poor Peoples Campaign, and his critique of government funding of wars instead of public services and social welfare programs. A virulent critic of capitalism, he advocated for a systemic redistribution of resources. The Status of the Dream Today: Educational Segregation More than fifty years later, if we take stock of the various aspects of Dr. Kings dream, it is clear that it remains largely unrealized.  Though the Civil Rights Act of 1964 outlawed racial segregation in schools, and a painful and bloody process of desegregation followed,  a May 2014 report from The Civil Rights Project at the University of California-Los Angeles found that schools have regressed to racial segregation over the last couple of decades. The study found that most white students attend schools that are 73 percent white, that the percentage of Black students in mostly minority schools has risen over the last two decades, that Black and Latino students are mostly sharing the same schools, and that the rise in segregation has been most dramatic for Latino students.  The study also found that segregation plays out across both race and class lines, with white and Asian students primarily attending middle-class schools, while black and Latino students are relegated to po or schools. Other studies show that black students face discrimination within schools that leads to them receiving more frequent and harsher discipline than their peers, which disrupts their educational process. The Status of the Dream Today: Voter Disenfranchisement Despite voter protections, racism still prohibits equal participation in democracy. As A. Gordon, a civil rights attorney wrote for The Root, passage of strict voter ID laws in 16 states are likely to bar many Black people from voting, as they are less likely to have state issued ID than persons of other races, and are more likely to be asked for ID than are white voters. Cuts to early voting opportunities are also likely to impact the Black population, who are more likely to take advantage of this service. Gordon also points out that implicit racial bias is likely to impact decisions made by those serving voters when issues of eligibility come up, and noted that a recent study found that legislators in support of stricter voter ID laws were more likely to respond to questions from a constituent when that person had a white name versus a name signaling Latino or African American heritage. The Status of the Dream Today: Workplace Discrimination While de jure  discrimination in the work place and hiring processes has been outlawed, de facto  racism has been documented by numerous studies over the years. Findings include that potential employers are more likely to respond to applicants with names they believe signal white race than those of other races; employers are  more likely to promote white men over all others;  and, faculty at universities are more likely to respond to prospective graduate students when they believe that person is a white male. Further, the persistent racial wage gap continues to show that the labor of white people is valued more than that of blacks and Latinos. The Status of the Dream Today: Housing Segregation Like education, the housing market remains segregated on the basis of race and class.  A 2012 study by the US Department of Housing and Urban Development  and the Urban Institute found that, though overt discrimination is mostly a thing of the past, subtle forms persist, and have clear negative consequences. The study found that real estate agents and housing providers routinely and systemically show more available properties to white people than they do to persons of all other races, and that this occurs across the nation. Because they have fewer options to choose from, racial minorities face higher housing costs. Other studies have found that Black and Latino homebuyers were disproportionately directed to unstable subprime mortgages, and as a result, were  far more likely than whites to lose their homes during the home mortgage foreclosure crisis. The Status of the Dream Today: Police Brutality In terms of police violence, since 2014, nationwide attention has turned to this deadly problem. Protests against the killing of unarmed and innocent black men and boys prompted many social scientists to revisit and republish data that show unequivocally that Black men and boys are racially profiled by police, and arrested, assaulted, and killed by officers at rates that far exceed those of other races. Critical work by the Department of Justice has brought improvements to many police departments across the nation, but the unending news of police killings of Black men and boys shows that the problem is widespread and persistent. The Status of the Dream Today: Economic Inequality Finally, Dr. Kings dream of economic justice for our nation is equally unrealized. Though we have minimum wage laws, the shift in work from stable, full-time jobs to contract and part-time work with minimum pay has left half of all Americans in or on the brink of poverty. The nightmare that King saw in the discrepancy between spending on war and spending on public services and social welfare has only gotten worse since then. And, instead of economic restructuring in the name of justice, we now live in the most economically unequal time in modern history, with the richest one percent controlling about half of all the worlds wealth. Black and Latino people continue to lag far behind white people and Asian Americans in terms of income and family wealth, which negatively impacts their quality of life, health, access to education, and overall life chances. We All Must Fight for the Dream The resurgent black Civil Rights movement, operating under the slogan Black Lives Matter, seeks to raise awareness of and combat these problems. But making Dr. Kings dream into a reality is not the work of black people alone, and it will never be a reality so long as those of us who are not burdened by racism continue to ignore its existence and consequences. Fighting racism, and creating a just society, are things for which each and every one of us bears responsibility- especially those of us who have been its beneficiaries.

Near Earth Objects essays

Near Earth Objects essays Near-Earth Objects are comets and asteroids that have been pushed by the gravitational attraction of nearby planets into orbits that allow them to enter the Earth's neighborhood. They are about 4.5 billion years and can range in size from pebbles or lumps of ice, to rocky or icy worlds nearly 1,000 kilometers across. An asteroid or comet may become a Near Earth Object when its trajectory intersects the orbit of the Earth or is within 0.3 Astronomical Units (distance between the earth and the sun). A Comet is a body revolving around the sun. A comet is characterized by a long, luminous tail, but only in the segment of the comets orbit when it passes closest to the sun. Composed mostly of water ice with rooted dust particles, comets originally formed in the cold outer planetary system while most of the rocky asteroids formed in the warmer inner solar system. A Meteor is a small solid body that enters a planet's atmosphere from outer space and raised to combustion by the friction resulting from its fast motion. An Asteroid is one of the many small or minor planets that are members of the solar system and that move in elliptical orbits primarily between the orbits of Mars and Jupiter. Some 65 million years ago dinosaurs and 75 percent of those species then on Earth seem to have been executed to extinction by the impact of a 10-kilometer-diameter (6-mile) NEO. The Tunguska event of 1908 in Siberia, warns the United States Air Force on small objects entering Earth's atmosphere, and particularly, the impact of some two dozen fragments of comet Shoemaker-Levy 9 with Jupiter in 1994 all underscore that dangerous impacts may occur today. The best estimate of the probability of a civilization-threatening collision in the next century is nearly one in 1,000. Estimates of the numbers of Near Earth Objects of different sizes can be made either by direct measurement using ground-based telescopes or inferred from the numbers and sizes of...

Explain Marx's 'general law of capitalist accumulation' and discuss Essay

Explain Marx's 'general law of capitalist accumulation' and discuss its contemporary relevance - Essay Example Marx’s earliest writing reflected a critique of the relationship between civil society and the state and progressively builds up to his dire prediction that capitalism would result in the rise of proletariat/working class and the ultimate reversal of fortunes as expressed in The General Law (Gurley, 1980). Ultimately, Marx’s The General Law predicts that capitalism would grow and expand to a point of self-destruction (Marx & Engels, 2007). The 2008 global financial crisis can therefore be seen as an example of the contemporary relevance of The General Law’s contention that capitalism would eventually dig its own grave by overproduction, greed, exploitation and alienation. This paper examines The General Law and its contemporary relevance. In order to put The General Law in its proper perspective, this paper will first identify and examine Marx’s political ideas culminating in The General Law and identify its contemporary relevance throughout. ... 187). For Marx, as reflected in The General Law and earlier writings, the forces of production, historical materialism and social relations would create conflicts which would lead to destruction rather than reconciliation (Elliot, 1978-78, p. 148). The 25 year old Karl Marx’s response to Hegel’s Der Philosphie des Rechts (Philosophy of Right) provides some insight into how Marx would eventually come to view the destructive forces of capitalism in The General Law. Marx honed in on Hegel’s â€Å"political science† (Jackson, 1990, p. 799). In this regard, Hegel defended the state and its constitutional structures claiming that this amalgamation of power was necessary for order in civil society (Depew, 1992, Chapter 2). Marx was quick to point out that the constitution should be nothing more than a reflection of man’s consciousness and this could only be accomplished if man was â€Å"the principle of the constitution† (Marx, 1977, p. 20). Marx (1 977) also sets the stage for the articulation of his critique of capitalism in The General Law and in general. Marx (1977) criticized Hegel’s reference to the state is far too abstract and that Hegel seems to forget that the state’s activities are carried out by man and reflects man’s own social qualities. According to Easton (1981), Marx was setting up his later argument that the state was nothing more than an instrument of control by the ruling classes. This argument would balloon into the neo-Marxist contention that the state was commandeered by those with â€Å"economic leverage† (Nordinger, Lowi, & Fabbrini, 1988, p. 875). The significance of economic gain in the ordering of society is a major theme in The General Law and the idea of economic

Info technology Essay Example | Topics and Well Written Essays - 500 words

Info technology - Essay Example This article mainly focuses on the approach to be implemented to improve the Supply Chain Management in order to effectively cut down on excess costs. The author discusses how different companies implement the present Supply Chain Management principle and expect different and better results whereas this is not possible. The author states in this article that to gain better profit margins and to gain a better hold over the market, each company has to come up with its own Supply Chain Management principle which suits that company. Despite the changes such as Globalization, Real-Time Supply Chain Process, Lean Management for Waste Reduction, Accounting Rules and Transparency of sales and acceptance, companies present since ninety years back function the same way as they did then. The author suggests the old business principles to be dropped and new improvised ones be implemented. The approach should be more of a strategy than being jut a principle. The first step is to design the a new architecture for the Supply Chain Management. The second step is to define the process, people and technology. The third step is to use resources effectively. The fourth and the final step is to include the scope, breadth and complexity of supply chains. Discussion: Supply Chain Management involves co-ordinating and integrating the flow of materials, information and finances from supplier to manufacturer to retailer to consumer both within and among companies (Ayers, 2000). The product flow involves the flow or movement of raw materials from the supplier to the manufacturer and the movement of products from the manufacturer to the wholesaler to retailer to the consumer. The information flow involves the flow of information such as transmitting orders and updating the status of delivery. Flow of finances includes transfer of credit, payment schedules, etc. Supply Chain Management makes use of